neuraminidase相关论文
Influenza neuraminidase(NA)is an important target for anti-influenza drugs design.Till now,there have been three anti-in......
3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuram
OBJECTIVE To explore the structure activity relationship of a series of flavone derivatives with influenza H1N1 neuramin......
Background The influenza virusneuraminidase (as known as sialidase; NA) is a type Ⅱ transmembrane glycoprotein located ......
Upon the outbreak of human cases of avian influenza virus(H7N9)infection in China since April 2013,the vaccine developme......
Inhibitory of H1N1 influenza virus-induced apoptosis by functionalized Selenium nanoparticles with A
As an effective antiviral agent,the clinical application of Arbidol is limited by the appearance of drug-resistant virus......
Mutation effects of neuraminidases and their docking with ligands: a molecular dynamics and free ene
A systematic study has been performed on neuraminidase (NA) mutations and NA-inhibitor docked complexes, with the aim to......
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Insights from investigating the interaction of oseltamivir (Tamiflu)with neuraminidase of the 2009 H
The neuraminidase (NA) of influenza virus is the target of anti-flu drugs oseltamivir and zanamivir.Clinical practic......
Molecular simulation study of the binding mechanism of [α-PTi2W10O40]7- for its promising broad-spec
Polyoxometalate (POM ) 举办有希望的抗病毒的活动。它显示出用途广泛的禁止的能力，高效率，和低毒性。试验性的试金证明包含 polyox......
QSAR and Pharmacophore Studies of Thiazolidine-4-carboxylic Acid Derivatives as Novel Influenza Neur
In order to understand the chemical-biological interactions governing their activities toward neuraminidase (NA), QSAR m......
In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo,we est......
In Vitro Anti-viral Activities and Structureactivity Relationship Studies of Flavones and Dihydrofla
From the bioassay tests,14 neuraminidase inhibitors(NIs) flavones and dihydroflavones derivatives from natural plants di......
在生物学里,没有什么比病毒更简单的了。它们粘附在细胞上,(侵入细胞内)脱壳,把自己的基因丢进去,然后分裂繁殖。但是,病毒的命名......
Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, ......
AIM:To investigate the role of glycylproline dipeptidylaminopeptidase(GPDA)isoenzyme in the diagnosis ofprimary hepatoc......
目的构建一种含H7N9禽流感病毒全长血凝素/神经氨酸酶/基质蛋白(HA/NA/M)基因的重组质粒,为核酸检测方法提供一种通用的阳性定量标......
Objective:To discuss the possibility of expressing the haemagglutinin-neuraminidase (HN) protein in prokaryotic system s......
目的探讨神经氨酸酶基因A(nanA)产物对感染肺炎球菌后仓鼠咽鼓管细胞表面糖化合物变化的作用.方法应用植物血凝素组织化学技术,比......
The epidemic of SARS in Guangdong province of China isbeginning to be restrained. In May 2003, Dr. ZhongNanshan, head o......
人禽流感(avian influenza)是人禽流行性感冒的简称,是由甲型流感病毒株的某些亚型引起的急性呼吸道传染病.通常情况下,禽流感病毒......
Early 2009, eight human infection cases of H5N1 highly pathogenic avian influenza (HPAI) virus, with 5 death cases, were......
Since the 2009 pandemic H1N1 swine-origin influenza A virus (09 S-OIV) has reminded the world about the global threat of......
STUDIES ON MONOCLONAL ANTIBODIES AGAINST HUMAN PLATELETS——A MONOCLONAL ANTIBODY TO HUMAN PLATELET GL
A monocloual antibody, SZ-2, reacts specifically on human platelets and megakaryocytes. The plate-lets from 10 normal d......
In this paper, we present a conductivity method for measuring the RBC (red blood cell)aggregation-sedimentation phenomen......
Inluenza remains a global problem,resulting in 250 000–500 000 deaths in non-pandemic years according to the most recen......
近年来,在几种临床疾病中记述了唾液酸苷酶(neuraminidase)活性缺陷的情况。Cantz等还发现以前被分类为Ⅰ型粘脂沉积症(mucolipid......
The most recent new emerging infection is the H5N6 inl uenza virus infection. This infection has just been reported from......
Hemagglutinin-neuraminidase (HN) protein was expressed in COS-7 cells, indicating that the expression of HN protein dri......
The alkaline phosphatases(APs)in three cell lines(GG,MM138,293)have been characterized by inhibition,thermostability,el......
本篇综述讨论了多种类型的抗病毒药物及其治疗前景,主要是针对于HIV病毒。这些药物作用于病毒感染的整个过程,包括病毒的进入、复......
Objective:To explore the potential effects of berberine on influenza virus infection both in vitro and in vivo.Methods:I......
Although the important role of the non-structural (NS1 and NEP) gene of influenza A in virulence of the virus is well es......
Hemagglutinin-neuramidinase(HN) is one of the most important surface structure proteins of the Newcastle disease virus(N......
Neuraminidase (NA) is one of the most important targets to screen the drugs of anti-influenza virus A and B. After virtu......
Objective:To determine whether the requirements for sialic acid varies and whether several types of silaic acid independ......
Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to ......
The neuraminidase (NA) in viral surface is one of the main subtype-specific antigen of influenza type A viruses.Neuramin......
Objective Currently, powdered Chinese herbal medicines(CHMs) were mainly evaluated through physical property, chemical d......
A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzy
The use of oseltamivir,widely stockpiled as one of the drugs for use in a possible avian influenza pandemic,has beenrep......
Screening and evaluation of commonly-used anti-influenza Chinese herbal medicines based on anti-neur
Anti-influenza Chinese herbal medicines(anti-flu CHMs) have advantages in preventing and treating influenza virus infect......
This research focused on the modification of the functional groups of oseltamivir as neuraminidase inhibitor against inf......
Dear Editor,Influenza A viruses(IAVs)are single-stranded,negative sense RNA viruses.IAV subtype is determined on the bas......
Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivativ
A series of ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives were synthesized and their in vitro anti-influenza v......
Alpinia zerumbet, a ginger plant with a multitude of medicinal properties: An update on its research
In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its ......
Polyoxometalate (POM) has promising antiviral activities.It shows broad-spectrum inhibiting ability,high efficiency,and ......
本文旨在建立以2009新型甲型H1N1流感病毒神经氨酸酶(neuraminidase,NA)为靶点的神经氨酸酶抑制剂(neuraminidase inhibitors,NAIs......
Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in hum
A simple,precise and rapid liquid chromatography-tandem mass spectrometry(LC-MS/MS) method has been developed and valida......
In fluenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination ......
